Array-based comparative genomic hybridization for genomic-wide screening of DNA copy number alterations in aggressive bone tumors

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Array-based comparative genomic hybridization for genomic-wide screening of DNA copy number alterations in aggressive bone tumors

BACKGROUND The genetic pathways of aggressive changes of bone tumors are still poorly understood. It is very important to analyze DNA copy number alterations (DCNAs), to identify the molecular events in the step of progression to the aggressive change of bone tissue. METHODS Genome-wide array-based comparative genomic hybridization (array CGH) was used to investigate DCNAs of 14 samples from ...

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Array-based comparative genomic hybridization (CGH) allows for the simultaneous examination of thousands of genomic loci at 1-2 Mb resolution. Copy number alterations detected by array-based CGH can aid in the identification and localization of cancer causing genes. Here we report the results of array-based CGH in a set of 125 primary colorectal tumors hybridized onto an array consisting of 246...

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ژورنال

عنوان ژورنال: Journal of Experimental & Clinical Cancer Research

سال: 2012

ISSN: 1756-9966

DOI: 10.1186/1756-9966-31-100